AP Top Headlines at 5:43 p.m. EDT

Stocks closed sharply lower on Wall Street Wednesday as dismal results from Target renewed fears that inflation is battering U.S. companies

Russia says that nearly 1,000 Ukrainian troops who doggedly defended a giant steelworks in Mariupol have surrendered

Doug Mastriano is not the only candidate who won a Republican primary on Tuesday after embracing former President Donald Trump’s lie that the 2020 election was stolen

President Joe Biden embarks for Asia on Thursday facing a new risk for the economy at home: a global economic slowdown caused by Russia’s invasion of Ukraine and the pandemic shutting down Chinese cities and factories

Shortly before police say he opened fire, the white gunman accused of killing 10 Black people at a Buffalo, New York, supermarket allowed a small group of people to see his long-simmering plans for the attack, which he had been chronicling for months in a private, online diary

COVID-19 cases are increasing in the United States — and could get even worse over the coming months, federal health officials warned in urging areas hardest hit to consider reissuing calls for indoor masking

NATO diplomats say national envoys have failed to reach a consensus about whether to start membership talks with Finland and Sweden

Friends and colleagues of Dr. John Cheng say they were not surprised the quiet, kind and calm sports medicine physician saved others by rushing at the gunman firing on a Southern California church luncheon

The U.S. Soccer Federation has reached milestone agreements to pay its men’s and women’s teams equally

Convicted pharmaceutical executive Martin Shkreli has been freed from prison after serving much of a seven-year prison sentence for lying to hedge fund investors and cheating investors in a drug company